Today is #InternetSlowdown Day — please share!

mostlysignssomeportents:

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All across the Internet, websites and services are staging a mass denial of service attack on themselves, to show the world what the world would look like if Big Cable and AT&T solicit bribes to decide which websites you can reach quickly, and which ones are going to go in the Internet slow-lane.

Read more…

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trms:

One look at the map explains why Turkey is crucial to U.S. anti-ISIS strategy…
…and why Congress is putting America at a disadvantage by leaving ambassador nominations languishing unconfirmed.
Bonus map of countries without US ambassadors via US Department of State. (pdf)
trms:

One look at the map explains why Turkey is crucial to U.S. anti-ISIS strategy…
…and why Congress is putting America at a disadvantage by leaving ambassador nominations languishing unconfirmed.
Bonus map of countries without US ambassadors via US Department of State. (pdf)

trms:

One look at the map explains why Turkey is crucial to U.S. anti-ISIS strategy…

…and why Congress is putting America at a disadvantage by leaving ambassador nominations languishing unconfirmed.

Bonus map of countries without US ambassadors via US Department of State. (pdf)


Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

Karen Gillan as Eliza Dooley

neurosciencestuff:

Broken signals lead to neurodegeneration 
Researchers from the RIKEN Brain Science Institute in Japan, in collaboration with Juntendo University and the Japan Science and Technology Agency, have discovered that a cell receptor widely involved in intracellular calcium signaling—the IP3R receptor—can be locked into a closed state by enzyme action, and that this locking may potentially play a role in the reduction of neuron signaling seen in neurodegenerative diseases such as Huntington’s and Alzheimer’s disease. 

In the research published today in the Proceedings of the National Academy of Sciences, the scientists reported experiments in human cells and a mouse model of Huntington’s disease revealing that transglutaminase type 2—a protein cross-linking enzyme elevated in the cells of patients with neurodegenerative diseases—interacts with the IP3R receptor to lock it in a closed non-functional conformation preventing it from fulfilling its essential calcium-releasing role. They identified a specific amino acid site on the receptor, Gln2746, where the modification takes place, deepening our understanding of how receptors are locked and potentially opening the door to studies on other functional proteins that are also regulated by conformational changes.
The IP3R channel, which is located in the endoplasmic reticulum, a protein assembly and transport compartment, plays a crucial role in intracellular calcium signaling, and is involved in a wide range of cell functions including mitochondrial energy production and the regulation of autophagy, the process through which cells consume and degrade unused components to maintain a healthy balance of functional proteins. Although autophagy is normally a mechanism that sustains cell maintenance, it can also trigger a loss of cell function and has been associated with prominent diseases including Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease.
In this work, the scientists propose a general model under which abnormal IP3R-mediated calcium signaling caused by the action of transglutaminase type 2 leads to cellular dysfunction and subsequently to the emergence of progressive brain dysfunction. Transglutaminase 2 activation is commonly associated with inflammation and stress, and its action on the IP3R channel might provide an explanation for the initiation and progression steps common to different neurodegenerative diseases.
According to Katsuhiko Mikoshiba, who led the study, “We think that the mechanism we identified in this study could provide us with a more general model of other diseases both of the brain and other parts of the body, where transglutaminase type 2 is upregulated. We hope that this insight could eventually lead to the development of new drug therapies for a number of neurodegenerative diseases that place a high burden on patients and society.”

neurosciencestuff:

Broken signals lead to neurodegeneration

Researchers from the RIKEN Brain Science Institute in Japan, in collaboration with Juntendo University and the Japan Science and Technology Agency, have discovered that a cell receptor widely involved in intracellular calcium signaling—the IP3R receptor—can be locked into a closed state by enzyme action, and that this locking may potentially play a role in the reduction of neuron signaling seen in neurodegenerative diseases such as Huntington’s and Alzheimer’s disease.

In the research published today in the Proceedings of the National Academy of Sciences, the scientists reported experiments in human cells and a mouse model of Huntington’s disease revealing that transglutaminase type 2—a protein cross-linking enzyme elevated in the cells of patients with neurodegenerative diseases—interacts with the IP3R receptor to lock it in a closed non-functional conformation preventing it from fulfilling its essential calcium-releasing role. They identified a specific amino acid site on the receptor, Gln2746, where the modification takes place, deepening our understanding of how receptors are locked and potentially opening the door to studies on other functional proteins that are also regulated by conformational changes.

The IP3R channel, which is located in the endoplasmic reticulum, a protein assembly and transport compartment, plays a crucial role in intracellular calcium signaling, and is involved in a wide range of cell functions including mitochondrial energy production and the regulation of autophagy, the process through which cells consume and degrade unused components to maintain a healthy balance of functional proteins. Although autophagy is normally a mechanism that sustains cell maintenance, it can also trigger a loss of cell function and has been associated with prominent diseases including Huntington’s disease, Alzheimer’s disease, and Parkinson’s disease.

In this work, the scientists propose a general model under which abnormal IP3R-mediated calcium signaling caused by the action of transglutaminase type 2 leads to cellular dysfunction and subsequently to the emergence of progressive brain dysfunction. Transglutaminase 2 activation is commonly associated with inflammation and stress, and its action on the IP3R channel might provide an explanation for the initiation and progression steps common to different neurodegenerative diseases.

According to Katsuhiko Mikoshiba, who led the study, “We think that the mechanism we identified in this study could provide us with a more general model of other diseases both of the brain and other parts of the body, where transglutaminase type 2 is upregulated. We hope that this insight could eventually lead to the development of new drug therapies for a number of neurodegenerative diseases that place a high burden on patients and society.”

surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.
surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O
Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.
Find out who Damon challenges here. 

i like him.

surfer-rosa3:

huffingtonpost:

Matt Damon Does Ice Bucket Challenge With Toilet Water For 800 Million Without Clean H2O

Matt Damon was conflicted when friends Jimmy Kimmel and Ben Affleck called on him to complete the ALS ice bucket challenge.

Find out who Damon challenges here. 

i like him.

themediafix:

Breaking news: The D.C. Appeals Court just killed Net Neutrality.

This could be the end of the Internet as we know it. But it doesn’t have to be. 

Tell the FCC to restore Net Neutrality: http://bit.ly/1p4kukb

mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland
mystery-bazaar:

Scotland

mystery-bazaar:

Scotland